There are those who will say, "we cannot simply rely on our senses to know the world." Is this actually true or does it just sound nice? Doesn't everything we actually know about the world come from our senses?

You could,if you were using the correct position of view. Everything we think we know,is not the world. Its but the obstructions and obstacles we view,and determine as such,their name,reasons,purpose,and every other aspect our little minds conclude and title as such. The world is but what we have concluded it as. Use the senses beyond the blood filled walls of comprehension. These are beyond the mortal senses used inside our material creations. Take a ride on one of your said neurons, and see what you can comprehend from its own reasoning.You have what everything has.The very nature of infinite and energy exceeding even the power of the atomic bomb. Think not with the format taught. Know with the format that has always been.