What are the disadvantages of having wisdom?

Knowledge can cause disadvantages but Wisdom is like insights you get after connecting your knowledge internally.

So Wisdom is only when you apply. Wisdom would be like statement of law and it works specifically when applied to a situation.

However knowledge can trigger emotions or moods. So knowledge has disadvantages.

When they say Ignorance is bliss, they are referring to the knowledge that can trigger some negative emotions.

Example: One person might come to know that he has cancer one day and this is a disadvantage because the person is already living a happy life day by day. This new factful information only will cause him discomforts even though it's a true statement.

So in this context, Ignorance can be bliss to him because atleast earlier he was happy and now he is only more worried.

Note: One cannot have wisdom(directly), one can only internalize wisdom when he finds something meaningful to him after an experience.

Example: One gets stomach ache daily and keeps experiencing daily for more than one month. Then one day he didn't get that pain and he reflects back thinking what he did differently today. So every day he might have eaten in a particular hotel but today he had not eaten in that hotel. This is like wisdom because he internalized within his mind like a bulb moment of idea. So Wisdom is like connecting the dots to get a new insight. It might always be delightful and helpful.